Plant Spotted Joe-Pye Weed in early spring or fall. Choose a location with full sun to partial shade and moist, well-drained soil. Space plants 2-4 feet apart. Water regularly to keep the soil consistently moist, especially during dry spells. Fertilize in early spring with a balanced fertilizer. Deadhead spent flowers to encourage more blooms and cut back stems to the ground in late fall or early spring to promote healthy growth. Divide clumps every 3-4 years to maintain vigor.