Plant JoJo Joe Pye Weed in early spring or fall. Choose a location with full sun to partial shade and well-drained, moist soil. Space plants 3-4 feet apart. Water regularly to keep the soil consistently moist, especially during dry spells. Fertilize with a balanced, slow-release fertilizer in early spring. Deadhead spent flowers to encourage more blooms. Cut back stems to the ground in late fall or early spring to promote healthy growth.