Variegated Solomon's Seal thrives in partial to full shade with well-draining, humus-rich soil. Maintain consistent moisture, especially during dry spells, to support its delicate arching stems and foliage. In spring, apply a balanced, slow-release fertilizer to encourage healthy growth. Prune back dead foliage in late autumn to prepare for the next growing season. Divide clumps every few years to prevent overcrowding and promote vigorous growth.